Replication gaps underlie BRCA-deficiency and therapy response
N. J. Panzarino, J. Krais, M. Peng, M. Mosqueda, S. Nayak, S. Bond, J. Calvo, K. Cong, M. Doshi, M. Bere, J. Ou, B. Deng, L. J. Zhu, N. Johnson, S. Cantor
This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.
bioRxiv · Sep 25, 2019Cancer Biology