B. Deng

Intermittent energy restriction inhibits tumor growth and enhances paclitaxel response in a transgenic mouse model of endometrial cancer

This study shows that intermittent energy restriction (IER) reduces tumor growth and improves paclitaxel response in a mouse model of endometrial cancer compared to low-fat diet.

Mesenchymal stem cells of the bone marrow raise infectivity of Plasmodium falciparum gametocytes

This study shows that bone marrow mesenchymal stem cells increase the infectivity of Plasmodium falciparum gametocytes, enhancing mosquito infection rates.

Histone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness

This study shows that acetylation of H2B.Z is critical for Toxoplasma gondii's growth, differentiation, and virulence.

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

Triangulation reduces the polygon of error for the history of Transeurasian

The paper addresses critiques of a Transeurasian language and population history study by revising datasets and methods, showing that the original findings remain valid despite objections.

Structural mechanism of leaflet-specific phospholipid modulation of a pentameric ligand-gated ion channel

The paper shows phosphatidylglycerol stabilizes the open state of ELIC by binding to a specific outer leaflet site, identified through structural and functional analyses.

TME induced TRAIL secretion from engineered macrophages for anti-tumor therapy

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

Blocking palmitoylation of Toxoplasma gondii myosin light chain 1 disrupts glideosome composition but has little impact on parasite motility

This study shows that blocking palmitoylation of T. gondii TgMLC1 disrupts its association with TgGAP45 but does not significantly affect parasite motility.

Replication gaps underlie BRCA-deficiency and therapy response

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.

Toxoplasma F-Box Protein 1 is Required for Daughter Cell Scaffold Function During Parasite Replication

This paper identifies TgFBXO1 as an F-box protein essential for daughter cell scaffold function in Toxoplasma gondii, demonstrating its role in parasite replication.

Enabling tools for Toxoplasma glycobiology

This paper identifies and validates glycogenes in Toxoplasma gondii and characterizes novel glycans, providing tools for further glycobiology research.