L. J. Zhu

This study identifies GPAA1 as a regulator of CD24 surface expression and shows that inhibiting GPAA1 enhances macrophage-mediated phagocytosis of ovarian cancer cells.

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.

This study identifies Breg as a batokine that regulates adipose thermogenesis and glucose homeostasis, showing its role in energy metabolism and potential therapeutic applications.

The paper introduces Phosphosite Scanning to identify functionally important phosphosites in multisite phosphorylated domains, demonstrating its application to Hcm1 in yeast.

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

This study shows that the C-terminal chromatin-binding domain of Ki-67, along with p53, prevents mitotic chromosome damage in human cells.

This study analyzes transcriptome, proteome, and phenotypic changes in trisomy 21 fibroblasts, revealing increased gene and protein expression and aneuploidy-related phenotypes like reduced viability and reliance on serine-driven lipid biosynthesis.

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.

This study shows calcineurin and Hog1 coordinate to control the cell cycle during stress by modulating transcription factors at multiple regulatory nodes.