Cell BiologybioRxiv
APOL1 Variant-Expressing Endothelial Cells Exhibit Autophagic Dysfunction and Mitochondrial Stress
A. Blazer, Y. Qian, M. P. Schlegel…·R. Clancy
This study shows that APOL1 risk variants in endothelial cells impair mitochondrial function, lysosome integrity, and autophagy, with IFN-gamma exacerbating these effects in heterozygous cells.
DOI 10.3389/fgene.2022.769936