Author

R. Clancy

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Research Focus:differential expression· 4 Organism:human· 4 Approach:experimental assay· 3 Approach:deep learning· 2 Assay:proteomics· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

C. Putterman· 3 shared J. Buyon· 3 shared J. Guthridge· 3 shared P. Izmirly· 3 shared A. Arazi· 2 shared A. Fava· 2 shared D. Wofsy· 2 shared H. M. Belmont· 2 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

C. Putterman

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Author profile →

5 papers

Recent·Most cited

Blood immunophenotyping identifies distinct kidney histopathology and outcomes in patients with lupus nephritis

A. Horisberger, A. Griffith, J. Keegan, A. Arazi, J. Pulford, E. Murzin, K. Howard, B. Hancock, A. Fava, T. Sasaki, T. Ghosh, J. Inamo, R. Beuschel, Y. Cao, K. Preisinger, , Accelerating Medicines Pa

The paper identifies three immunologically distinct groups in lupus nephritis patients based on blood immunophenotyping, correlating with histopathology, treatment response, and renal outcomes.

bioRxiv · Jan 14, 2024Immunology

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritis

P. Hoover, D. J. Lieb, J. Kang, S. Li, M. Peters, C. Raparia, A. Arazi, T. Eisenhaure, S. S. Gurajala, Q. Xiao, R. Mishra, M. Spurrell, R. Menon, M. Kretzler, J. Chen, , A. Davidson

This study identifies conserved myeloid subsets and disease-associated gene expression changes in kidney injury across lupus mouse models and human patients with lupus nephritis.

bioRxiv · Jun 24, 2023 · PreprintImmunology

Real-time dynamic single-molecule protein sequencing on an integrated semiconductor device

B. D. Reed, M. J. Meyer, V. Abramzon, O. Ad, P. Adcock, F. R. Ahmad, G. Alppay, J. A. Ball, J. Beach, D. Belhachemi, A. Bellofiore, M. Bellow, J. Felipe Beltran, A. Betts, M. Wadud Bhuiya, , X. Ma

This paper introduces a method for real-time single-molecule protein sequencing using a semiconductor device, capable of detecting peptides and post-translational modifications with high sensitivity.

bioRxiv · Jan 4, 2022Biophysics

APOL1 Variant-Expressing Endothelial Cells Exhibit Autophagic Dysfunction and Mitochondrial Stress

A. Blazer, Y. Qian, M. P. Schlegel, J. Buyon, K. Cadwell, M. Cammer, S. Heffron, F.-X. Liang, S. Mehta-Lee, T. Niewold, S. Rasmussen, R. Clancy

This study shows that APOL1 risk variants in endothelial cells impair mitochondrial function, lysosome integrity, and autophagy, with IFN-gamma exacerbating these effects in heterozygous cells.

bioRxiv · Mar 18, 2020Cell Biology

Insights from Comparison of the Renal and Skin Single Cell Transcriptomes in Lupus Nephritis

E. Der, H. Suryawanshi, P. Morozov, M. Kustagi, B. Goilav, S. Ranabathou, P. Izmirly, R. Clancy, H. M. Belmont, M. Koenigsberg, M. Mokrzycki, H. Rominieki, J. Graham, J. Rocca, N. Bornkamp, , C. Putterman

This study uses scRNA-seq to analyze renal and skin biopsies from lupus nephritis patients, identifying IFN signatures and fibrotic pathways associated with disease heterogeneity and non-response.

bioRxiv · Dec 31, 2019 · PreprintImmunology