Cell BiologybioRxiv
Acetylation-mediated phase control of the nucleolus regulates cellular acetyl-CoA responses
R. Houston, S. Sekine, M. J. Calderon…·Y. Sekine
The paper shows that acetyl-CoA depletion disrupts nucleolar integrity, activates p53 via ribosomal proteins, and is mediated by class IIa HDACs regulating nucleolar phase state.
DOI 10.1371/journal.pbio.3000981