Author

M. P. Tobin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Organism:human· 1

Frequent Co-Authors

L. J. Dooling· 2 shared A. H. Chang· 1 shared B. H. Hayes· 1 shared C. R. Pfeifer· 1 shared D. Discher· 1 shared D. E. Discher· 1 shared E. G. Ricci-De Lucca· 1 shared H. Zhu· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

L. J. Dooling

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2 papers

Recent·Most cited

Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

B. H. Hayes, M. Wang, H. Zhu, S. H. Phan, J. C. Andrechak, A. H. Chang, L. J. Dooling, M. P. Tobin, T. Marchena, D. Discher

This study shows that chromosomal instability in cancer cells can enhance macrophage-mediated immune responses and induce a broad anti-tumor IgG response, improving survival when combined with CD47-SIRP checkpoint disruption.

bioRxiv · Apr 2, 2023 · PreprintCancer Biology

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

C. R. Pfeifer, M. P. Tobin, S. Cho, M. Vashisth, L. J. Dooling, L. L. Vasquez, E. G. Ricci-De Lucca, K. T. Simon, D. E. Discher

The paper shows that high nuclear curvature causes lamin-B dilution and rupture, with lamin-A also contributing under high strain rates, suggesting a viscoplastic response to mechanical stress.

bioRxiv · Oct 13, 2021Biophysics