Author

L. J. Dooling

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Bioengineering· 1 Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Organism:human· 2

Frequent Co-Authors

D. E. Discher· 3 shared J. Irianto· 3 shared B. H. Hayes· 2 shared C. R. Pfeifer· 2 shared J. C. Andrechak· 2 shared M. P. Tobin· 2 shared M. Vashisth· 2 shared A. H. Chang· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersBioengineering

D. E. Discher

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Differential modulation of cellular phenotype and drug sensitivity by extracellular matrix proteins in primary and metastatic pancreatic cancer cells

O. H. Usman, S. Kumar, R. R. Walker, G. Xie, H. Sumajit, A. R. Jalil, S. Ramakrishnan, L. J. Dooling, Y. J. Wang, J. Irianto

This study shows that ECM proteins differentially affect morphology, proliferation, and drug sensitivity in primary but not metastatic pancreatic cancer cells, with transcriptomic changes in primary cells.

Molecular Biology of the Cell · Dec 1, 2023Peer-reviewedCancer Biology

Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

B. H. Hayes, M. Wang, H. Zhu, S. H. Phan, J. C. Andrechak, A. H. Chang, L. J. Dooling, M. P. Tobin, T. Marchena, D. Discher

This study shows that chromosomal instability in cancer cells can enhance macrophage-mediated immune responses and induce a broad anti-tumor IgG response, improving survival when combined with CD47-SIRP checkpoint disruption.

bioRxiv · Apr 2, 2023 · PreprintCancer Biology

Cooperative phagocytosis underlies macrophage immunotherapy of solid tumours and initiates a broad anti-tumour IgG response

J. C. Andrechak, L. J. Dooling, B. H. Hayes, S. Kadu, W. Zhang, R. Pan, M. Vashisth, J. Irianto, C. M. Alvey, D. E. Discher

This study shows engineered macrophages using cooperative phagocytosis eliminate solid tumours and induce anti-tumour IgG, improving immunotherapy outcomes.

bioRxiv · Jan 1, 2022Bioengineering

Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

C. R. Pfeifer, M. P. Tobin, S. Cho, M. Vashisth, L. J. Dooling, L. L. Vasquez, E. G. Ricci-De Lucca, K. T. Simon, D. E. Discher

The paper shows that high nuclear curvature causes lamin-B dilution and rupture, with lamin-A also contributing under high strain rates, suggesting a viscoplastic response to mechanical stress.

bioRxiv · Oct 13, 2021Biophysics

Rescue of DNA damage in cells after constricted migration reveals bimodal mechano-regulation of cell cycle

Y. Xia, C. R. Pfeifer, K. Zhu, J. Irianto, D. Liu, K. Pannell, E. J. Chen, L. J. Dooling, R. A. Greenberg, D. E. Discher

The paper investigates DNA damage and cell cycle effects during constricted cell migration, finding a bimodal relationship between DNA damage and cell cycle regulation.

bioRxiv · Dec 30, 2018Cell Biology