Author

D. Discher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:chromatin & epigenetic regulation· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

M. Wang· 3 shared B. Hayes· 2 shared J. Irianto· 2 shared L. Dooling· 2 shared M. P. Tobin· 2 shared M. Tobin· 2 shared Y. Xia· 2 shared A. Anlas· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersCancer Biology

M. Wang

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Lipid Nanoparticle-Associated Inflammation is Triggered by Sensing of Endosomal Damage: Engineering Endosomal Escape without Side Effects

S. Omo-Lamai, Y. Wang, M. N. Patel, E.-o. Essien, M. Shen, A. Majumder, C. Espy, J. Wu, B. Channer, M. P. Tobin, S. Murali, T. E. Papp, R. Maheshwari, L. Wang, L. S. Chase, , J. S. Brenner

This paper identifies that lipid nanoparticle-induced inflammation arises from endosomal membrane damage and proposes strategies to mitigate it through galectin inhibition or ESCRT-recruiting lipids.

bioRxiv · Apr 16, 2024 · PreprintBioengineering

Chromosomal instability can favor macrophage-mediated immune response and induce a broad, vaccination-like anti-tumor IgG response

B. H. Hayes, M. Wang, H. Zhu, S. H. Phan, J. C. Andrechak, A. H. Chang, L. J. Dooling, M. P. Tobin, T. Marchena, D. Discher

This study shows that chromosomal instability in cancer cells can enhance macrophage-mediated immune responses and induce a broad anti-tumor IgG response, improving survival when combined with CD47-SIRP checkpoint disruption.

bioRxiv · Apr 2, 2023 · PreprintCancer Biology

Confinement with Myosin-II suppression increases heritable loss of chromosomes, using live-cell ChReporters

B. Hayes, P. Zhu, M. Wang, C. Pfeifer, Y. Xia, S. Phan, J. Andrechak, J. Du, M. Tobin, A. Anlas, L. Dooling, J. Irianto, M. Lampson, D. Discher

The paper uses live-cell ChReporters to show that Myosin-II suppression in confined mitosis increases heritable chromosome loss, independent of spindle assembly checkpoint in 3D and 2D.

bioRxiv · Feb 25, 2023 · PreprintCell Biology

Small, fat-filled lipid droplets remain spherical as they indent a nucleus, dilute the lamina, and cause rupture

I. Ivanovska, M. Tobin, L. Dooling, D. Discher

bioRxiv · Sep 1, 2022 · PreprintCell Biology

Scaling concepts in 'omics: nuclear lamin-B scales with tumor growth and predicts poor prognosis, whereas fibrosis can be pro-survival

M. Vashisth, D. Discher, S. Cho, J. Irianto, Y. Xia, M. Wang, B. Hayes, F. Jafarpour, A. Liu, R. G. Wells

The paper identifies scaling relationships between genes in cancer data, finding LMNB1 correlates with poor prognosis while fibrosis markers predict better survival.

bioRxiv · Feb 25, 2021 · PreprintCancer Biology