A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections
T. Barman, M. Kumar, T. Chaira, S. Singhal, T. Mathur, V. Kalia, R. Gangadharan, M. Rao, M. Pandya, P. Bhateja, R. Sood, D. Upadhyay, S. Varughese, A. Yadav, L. Sharma, , V. S. Raj
This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.
bioRxiv · Sep 8, 2022 · PreprintMicrobiology