L. Sharma

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

Sse1, Hsp110 chaperone of yeast, controls the cellular fate during Endoplasmic Reticulum-stress

This study shows that Sse1, a yeast Hsp110 chaperone, interacts with ER-UPR sensors and regulates ER protein homeostasis, ribosome reorganization, and cell division arrest during ER stress.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections

This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.

Actin filaments act as a size-dependent diffusion barrier around centrosomes

The paper quantifies size-dependent diffusion barriers around centrosomes, showing branched actin filaments restrict molecule access based on size.

Spatio-temporal modelling for the evaluation of an altered Indian saline Ramsar site and its drivers for ecosystem management and restoration

This study uses spatio-temporal modeling to analyze changes in Sambhar wetland, India, identifying drivers of ecosystem degradation and implications for conservation and restoration.

Identification of potent and safe antiviral therapeutic candidates against SARS-CoV-2

This study identifies 24 FDA-approved compounds that inhibit SARS-CoV-2 replication, with five showing high safety indices and blocking S protein-mediated cell fusion.

Type I Interferon Limits Viral Dissemination-Driven Clinical Heterogeneity in a Native Murine Betacoronavirus Model of COVID-19

This study establishes a murine model of COVID-19 using MHV-A59 and shows that type-I interferons limit viral dissemination, reducing lethality and recapitulating key clinical features.

Worldwide recombination in emergent white-nose syndrome pathogen Pseudogymnoascus destructans

This study detects recombination in the clonal fungus Pseudogymnoascus destructans using clone-corrected linkage disequilibrium analysis, revealing sexual reproduction in European populations and parasexual recombination in North American populations.

A Maxent modelling with a geospatial approach for the Habitat suitability of Flamingos in an Evanescing Ramsar site (Sambhar Lake, India) over the changing climatic scenarios

This study uses Maxent modeling to assess habitat suitability for flamingos in Sambhar Lake, India, under changing climate scenarios, finding that anthropogenic activities have reduced suitable habitat.