M. Rao

Evaluating the likelihood for areas important for conservation to be recognized as Other Effective area-based Conservation Measures

The paper evaluates indicators to identify sites that could qualify as OECMs, finding most potential OECMs are in good condition but none meet all criteria, while protected areas also mostly fail.

Development and optimization of a diluted whole blood ELISpot assay to test immune function

This study develops and optimizes a diluted whole blood ELISpot assay to assess immune function in septic patients, showing it can measure cytokine responses under various conditions.

Temporal Changes in Innate and Adaptive Immunity During Sepsis as Determined by ELISpot

This study uses ELISpot to track changes in innate and adaptive immunity during sepsis and shows it can detect immune therapy effects.

A survey of Rare Disease awareness among healthcare professionals and researchers in India

This study surveys RD awareness among healthcare professionals and researchers in India, finding low awareness and recommending improved campaigns and policies.

A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections

This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.

Protein as evolvable functionally-constrained amorphous matter

The paper models proteins as amorphous materials using graph representations to study functional features and their evolutionary emergence.

Optimal reliability, robustness and control of nucleus centering in fission yeast is contingent on nonequilibrium force patterning

The paper shows that optimal nucleus centering in fission yeast relies on nonequilibrium force patterns from microtubule bundles, with wild-type cells achieving optimal reliability and robustness.

FIB-SEM analysis on three-dimensional structures of growing organelles in wild Chlorella pyrenoidosa cells

This study uses FIB-SEM to analyze 3D organelle structures in Chlorella pyrenoidosa during growth stages, revealing changes in mitochondria, chloroplasts, and starch grains.

Single-cell transcriptome analysis reveals evolutionarily conserved features during the transition from normal breast stromal cells to cancer-associated fibroblasts

This study identifies conserved CAF subtypes in human and mouse breast tissues and reveals shared molecular mechanisms in their transition from normal stromal cells.

RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release from Enteroendocrine Cells

This study shows RET signaling in the adult intestine limits PYY release from L-cells, which is necessary for normal gut motility in male mice.

Active emulsions in living cell membranes driven by contractile stresses and transbilayer coupling

The paper investigates how active contractile stresses and transbilayer coupling drive the formation of mesoscopic domains in cell membranes containing GPI-APs and lipids.

Cellular compartmentalisation and receptor promiscuity as a strategy for accurate and robust inference of position during morphogenesis

The paper shows how cells use compartmentalisation and multiple receptors to accurately infer their position during morphogenesis, using Drosophila wing disc development as a case study.

A SARS-CoV-2 Spike Ferritin Nanoparticle Vaccine is Protective and Promotes a Strong Immunological Response in the Cynomolgus Macaque Coronavirus Disease 2019 (COVID-19) Model

This study evaluates a SARS-CoV-2 Spike ferritin nanoparticle vaccine in cynomolgus macaques, showing strong immunological responses and protection against infection.

Active Segregation Dynamics in the Living Cell

The paper develops an active version of Flory-Huggins theory to model nonequilibrium phase segregation in living cells driven by active stresses, highlighting unique dynamics like anomalous growth and mesoscale segregation.

SMC protein RecN drives RecA filament translocation and remodelling for in vivo homology search

This study identifies RecN as essential for RecA filament translocation and remodelling during homology search in Caulobacter, revealing a novel search strategy involving directional movement and dynamic filament changes.

A Remarkable Genetic Shift in a Transmitted/Founder Virus Broadens Antibody Responses Against HIV-1

The paper identifies a genetic shift in an HIV-1 transmitted/founder virus that leads to broader antibody responses by altering the V2 domain structure.

A spike-ferritin nanoparticle vaccine induces robust innate immune activity and drives polyfunctional SARS-CoV-2-specific T cells

This study evaluates a spike-ferritin nanoparticle vaccine with adjuvants, showing enhanced T cell responses and cross-reactivity against SARS-CoV and other coronaviruses.

Acyclovir Improves the Efficacy of Chemoradiation in Nasopharyngeal Cancer Containing the Epstein Barr Virus Genome

This study shows that adding acyclovir to chemoradiation reduces viability of EBV-infected NPC cells by increasing TK and apoptosis markers.

Glycan processing in the Golgi - optimal information coding and constraints on cisternal number and enzyme specificity

The paper quantitatively analyzes tradeoffs between Golgi cisternal number and enzyme specificity to determine optimal conditions for synthesizing complex glycan distributions.

Assemblies of F-actin and myosin-II minifilaments: steric hindrance and stratification at the membrane cortex

The paper investigates how steric hindrance and stratification affect actomyosin organization, showing that simulations and microscopy reveal stratified patterns in vitro that differ from in vivo observations.

Gut-innervating nociceptor neurons protect against enteric infection by modulating the microbiota and Peyer’s patch microfold cells

This study shows gut-innervating nociceptors protect against Salmonella typhimurium infection by modulating microbiota and Peyer’s patch microfold cells.