S. Singhal

Molecular early burst associated with the diversification of birds at the K-Pg boundary

The paper identifies a molecular early burst in avian evolution around the K-Pg boundary, linked to shifts in substitution rates and allometric scaling relationships.

A novel fluorobenzothiazole RBx 10080758 as a dual inhibitor against bacterial GyraseB (GyrB) and Topoisomerase IV (parE) of Gram-positive pathogens causing skin and respiratory infections

This paper evaluates a novel fluorobenzothiazole inhibitor, RBx 10080758, showing potent in vitro and in vivo activity against drug-resistant Gram-positive bacteria by dual targeting Gyrase B and Topoisomerase IV.

Deep learning can predict multi-omic biomarkers from routine pathology images: A systematic large-scale study

This study shows deep learning can predict multi-omic biomarkers from H&E-stained cancer slides, with 50% of models achieving AUC > 0.633 across 32 cancer types.

Evaluation of a predictive method for the H&E-based molecular profiling of breast cancer with deep learning

The paper validates a deep learning method that predicts breast cancer biomarkers from H&E slides with high accuracy in a clinical setting.

Diversification, disparification, and hybridization in the desert shrubs Encelia

The paper investigates diversification and disparification in Encelia, showing rapid phenotypic evolution and hybridization across environmental gradients.

Natural selection maintains species despite widespread hybridization in the desert shrub Encelia

The paper investigates how natural selection maintains species boundaries in hybridizing desert shrubs, identifying ecological mechanisms that counteract gene flow.

A tale of winglets: evolution of flight morphology in stick insects

This study examines flight morphology variation in stick insects, finding that intermediate wing sizes are rare and that wing and body size are inversely correlated.

Dispersal predicts hybrid zone widths across animal diversity: Implications for species borders under incomplete reproductive isolation

The paper examines how dispersal and mtDNA distance explain variation in hybrid zone widths across 135 animal taxon pairs, finding dispersal explains >30% of variation.

Adaptations of an RNA virus to increasing thermal stress

This study evolves an RNA virus under different thermal stress regimes and finds that gradual temperature increases lead to better initial survival at high temperatures, though final survival and mutation rates are not significantly affected.