Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias
L. Hinze, M. Pfirrmann, S. Karim, J. Degar, C. McGuckin, D. Vinjamur, J. Sacher, K. Stevenson, D. Neuberg, D. Bauer, F. Wagner, K. Stegmaier, A. Gutierrez
This study identifies a synthetic lethal interaction between Wnt pathway activation and asparaginase in drug-resistant leukemias, showing that Wnt/STOP signaling can sensitize resistant cells to asparaginase.
bioRxiv · Sep 12, 2018Cancer Biology