S. Karim

Bisphenol A and its Analogues Alter Appetite Control in Zebrafish

This study shows that bisphenol A and its analogues increase eating behavior in zebrafish larvae by altering gene expression related to appetite regulation.

Identification of Alpha-Gal conjugated Lipids in Saliva of Lone-Star Tick (Amblyomma americanum)

This study identifies alpha-gal conjugated lipid antigens in Lone-Star tick saliva and shows their ability to activate basophils.

Tick bite-induced Alpha-Gal Syndrome and Immunologic Responses in an Alpha-Gal Deficient Murine Model

This study investigates how different tick species influence the development of Alpha-Gal Syndrome in a genetically modified mouse model by analyzing immune responses and gene expression.

Ticks without borders: Microbial communities of immature Neotropical tick species parasitizing migratory landbirds along northern Gulf of Mexico

This study examines microbial communities in ticks parasitizing migratory birds in the Gulf of Mexico, identifying pathogenic microbes and their potential role in tick-borne pathogen spread.

Tick Innate Immune Responses to Hematophagy and Ehrlichia Infection at Single-Cell Resolution

This study uses single-cell RNA sequencing to analyze hemocyte populations in ticks during hematophagy and Ehrlichia infection, identifying distinct subpopulations and their gene expression changes.

Ehrlichia chaffeensis co-opts phagocytic hemocytes for systemic dissemination in the Lone Star tick, Amblyomma americanum

This study shows granulocytes in the Lone Star tick play dual roles in controlling and facilitating Ehrlichia chaffeensis infection.

Honey bee Apis mellifera L. Responses to Oxidative Stress Induced by Pharmacological and Pesticide Compounds

This study examines the effects of various pharmacological and pesticide compounds on honey bee survival and gene expression, finding significant toxicological impacts and gene regulation changes.

Rickettsia parkeri Hijacks Tick Hemocytes to Manipulate Cellular and Humoral Transcriptional Responses

This study identifies five hemocyte populations in ticks and shows Rickettsia parkeri infects phagocytic hemocytes, altering immune gene expression and phagocytosis.

An exploratory study on the microbiome of northern and southern populations of Ixodes scapularis ticks predicts changes and unique bacterial interactions

This study compares the microbiome of northern and southern Ixodes scapularis ticks using metagenomic sequencing and network analysis to identify bacterial interactions and differences.

Changes in microbial composition, diversity, and functionality in the Amblyomma maculatum microbiome following infection with Rickettsia parkeri

This study examines how Rickettsia parkeri infection and blood meal affect the microbiome composition, diversity, and functionality of Amblyomma maculatum ticks across their life cycle.

Perturbations of the AMI1 IAM-amidohydrolase expression trigger plant stress responses in Arabidopsis thaliana

This study shows that AMI1, an IAM amidohydrolase, converts IAM to IAA and its repression under osmotic stress triggers ABA biosynthesis, linking auxin homeostasis to plant stress responses.

Tick-Borne bacterial and protozoan animal pathogens shape the native microbiome within Hyalomma anatolicum anatolicum and Rhipicephalus microplus tick vectors

This study examines the microbiome of two tick species, revealing microbial composition differences between infected and uninfected individuals and detecting potential cross-infections with pathogens.

Determining the link between alpha-gal-containing antigens in North American ticks and red meat allergy

This study identifies the presence of alpha-gal in the salivary glands of two tick species and links it to red meat allergy through IgE antibody responses.

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

This study identifies a synthetic lethal interaction between Wnt pathway activation and asparaginase in drug-resistant leukemias, showing that Wnt/STOP signaling can sensitize resistant cells to asparaginase.