K. Stevenson

Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas

This study shows that ATRX loss primes glioma cells for innate immune recognition, while IDH1R132H mutation suppresses immune signaling, which can be reversed by IDH1 inhibition.

Polio Virotherapy of Malignant Glioma Engages the Tumor Myeloid Infiltrate and Induces Diffuse Microglia Activation

This study investigates how PVSRIPO virotherapy activates microglia and myeloid cells in gliomas, leading to antitumor inflammation and improved outcomes when combined with PD1/PD-L1 blockade.

Glioblastoma extracellular vesicles influence glial cell hyaluronic acid deposition to promote invasiveness

This study identifies how GBM extracellular vesicles containing podocalyxin promote astrocyte hyaluronic acid deposition, enhancing GBM invasiveness.

The development of ovine gastric and intestinal organoids for studying ruminant host-pathogen interactions

This paper develops ovine gastric and intestinal organoids to study host-pathogen interactions in ruminants, showing they maintain tissue-like transcriptomes and can be infected by pathogens.

Increased apoptotic priming of glioblastoma enables therapeutic targeting by BH3-mimetics

This study shows that glioblastoma (GBM) is highly sensitive to BH3-mimetics due to elevated anti-apoptotic BCL-xL and MCL-1 expression, which can be therapeutically targeted.

Low-dose lung radiotherapy for COVID-19 lung disease: a pre-clinical efficacy study in a bleomycin model of pneumonitis.

This study evaluates low-dose lung radiotherapy (LDLR) in a bleomycin pneumonitis model, finding that 1.0 Gy LDLR improves recovery and reduces inflammation, particularly in moderate cases.

Quantitative in vivo bioluminescence imaging of orthotopic patient-derived glioblastoma xenografts

This paper demonstrates the use of iRFP expression in patient-derived glioblastoma cells for non-invasive, quantitative monitoring of tumor growth in vivo.

Ultra-Low-Cost Integrated Silicon-based Transducer for On-Site, Genetic Detection of Pathogens

This paper introduces a low-cost silicon-based transducer (TriSilix) for real-time, quantitative pathogen detection using PCR and RPA, demonstrating detection of SARS-CoV-2 and M. avium subsp. paratuberculosis at single-bacterium levels.

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

This study identifies a synthetic lethal interaction between Wnt pathway activation and asparaginase in drug-resistant leukemias, showing that Wnt/STOP signaling can sensitize resistant cells to asparaginase.

Detection of Mycobacterium leprae DNA in soil; Multiple needles in the haystack?

This study detects M. leprae DNA in soil from regions with leprosy patients, armadillos, and red squirrels, suggesting environmental reservoirs may contribute to transmission.