F. Wagner

High resolution mapping of the breast cancer tumor microenvironment using integrated single cell, spatial and in situ analysis of FFPE tissue

This paper integrates single cell, spatial, and in situ technologies to analyze FFPE breast cancer tissue, revealing molecular insights into tumor subtypes and progression.

Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.

The paper identifies 389 small molecules and 813 host targets that inhibit SARS-CoV-2 infection through in vitro and in vivo testing, using computational integration of drug activity and cellular networks.

Phenotyping in the era of genomics: MaTrics a digital character matrix to document mammalian phenotypic traits coded numerically

MaTrics provides a digital matrix of mammalian phenotypes linked to genomes, highlighting knowledge gaps and enabling genomic-phenomic comparisons.

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic

The paper identifies Fostamatinib as a potential repurposing drug for acute lung injury by reducing MUC1 protein levels in preclinical models.

Extensive proteomic and transcriptomic changes quench the TCR/CD3 activation signal of latently HIV-1 infected T cells

This study identifies proteomic and transcriptomic changes in HIV-1 latently infected T cells that render them TCR/CD3 activation-inert, and shows that targeting specific signaling nodes can restore responsiveness and trigger HIV-1 reactivation.

Armadillo repeat-containing protein 1 is a dual localization protein associated with mitochondrial intermembrane space bridging complex

The paper identifies ArmC1 as a new subunit of the MICOS/MIB complex that localizes to both cytosol and mitochondria, affecting mitochondrial distribution without altering cristae structure or function.

Integrating single-cell RNA-Seq with spatial transcriptomics in pancreatic ductal adenocarcinoma using multimodal intersection analysis

This study integrates single-cell RNA-Seq and spatial transcriptomics data from pancreatic cancer tissue to map cell type spatial distributions and infer tissue architecture.

Dynamic architecture of the Escherichia coli structural maintenance of chromosomes (SMC) complex, MukBEF

The paper examines how nucleotide binding and ATP hydrolysis affect the architecture of the Escherichia coli SMC complex MukBEF.

Widespread transcriptional scanning in the testis modulates gene evolution rates

The paper maps gene expression in human spermatogenesis and finds that expressed genes have fewer germline mutations, suggesting transcriptional scanning reduces DNA damage and influences gene evolution rates.

Synthetic Lethality of Wnt Pathway Activation and Asparaginase in Drug-Resistant Acute Leukemias

This study identifies a synthetic lethal interaction between Wnt pathway activation and asparaginase in drug-resistant leukemias, showing that Wnt/STOP signaling can sensitize resistant cells to asparaginase.