SUFFICIENT ACTIVITY OF THE UBIQUITIN PROTEASOME SYSTEM IN AGED MICE AND DURING RETINAL DEGENERATION SUPPORTS DHFR-BASED CONDITIONAL CONTROL OF PROTEIN ABUNDANCE IN THE RETINA
H. Peng, P. Ramadurgum, D. Woodard, S. Daniel, M. Renwick, B. Aredo, S. Datta, B. Chen, R. Ufret-Vincenty, J. Hulleman
This study evaluates the effectiveness of a DHFR-based system for conditional protein control in aged and retinal degeneration mouse models, showing successful degradation despite compromised UPS in some models.
bioRxiv · Apr 13, 2021Physiology