PhysiologybioRxiv
SUFFICIENT ACTIVITY OF THE UBIQUITIN PROTEASOME SYSTEM IN AGED MICE AND DURING RETINAL DEGENERATION SUPPORTS DHFR-BASED CONDITIONAL CONTROL OF PROTEIN ABUNDANCE IN THE RETINA
H. Peng, P. Ramadurgum, D. Woodard…·J. Hulleman
This study evaluates the effectiveness of a DHFR-based system for conditional protein control in aged and retinal degeneration mouse models, showing successful degradation despite compromised UPS in some models.
DOI 10.1016/j.isci.2022.104206