S. Datta

Syntaxin11 Deficiency Inhibits CRAC Channel Priming to Suppress Cytotoxicity and Gene Expression in T Lymphocytes Independent of Membrane Trafficking.

This study shows Syntaxin11 primes Orai1 for CRAC channel function, affecting T cell cytotoxicity and gene expression without impacting membrane trafficking.

The B-box protein BBX13/COL15 suppresses photoperiodic flowering by attenuating the action of CONSTANS in Arabidopsis

This study identifies BBX13/COL15 as a negative regulator of flowering in Arabidopsis under long-day conditions by inhibiting CO-mediated activation of FT.

Whole-genome duplication in the Multicellularity Long Term Evolution Experiment

This study shows that diploid yeast under selection for larger multicellular size rapidly undergoes spontaneous whole-genome duplication, which persists and facilitates adaptation through increased genetic variation.

Time course metabolomics and 13CO2 mapping establish BBX31/miP1b mediated metabolic readjustments conferring UV-B tolerance in Arabidopsis

This study identifies BBX31/miP1b-mediated metabolic changes in Arabidopsis under UV-B stress using metabolomics and 13CO2 tracing, showing increased phenylalanine and other protective metabolites.

Select Gut Bacteria Promote Mosquito Larval Growth by Contributing Protease Activity and Optimal Ionic Microenvironment for Protein Digestion

This study identifies specific gut bacteria that enhance mosquito larval growth by providing protease activity and maintaining an optimal ionic environment for protein digestion.

Implication of structural constrains facilitating the functional evolution of Pseudomonas aeruginosa KPR2 into a versatile α-keto acid reductase.

The paper investigates the structural and functional evolution of PaKPR2 in Pseudomonas aeruginosa, revealing how structural constraints enable its versatility as a keto-acid reductase.

Design and fabrication of flexible biodegradable microelectrode array for recording electrocorticography signals

This paper designs and fabricates a biodegradable microelectrode array for recording electrocorticography signals in rats, showing minimal tissue damage and potential for chronic brain activity monitoring.

ABI3 regulates ABI1 function to control cell length in primary root elongation zone

This study shows ABI3 regulates JAZ1 and ABI1 to control cell length in primary root elongation by modulating protonation of the apoplast.

Reducing the vicissitudes of heterologous prochiral substrate catalysis by alcohol dehydrogenases through machine learning algorithms

This study uses machine learning to classify substrates for alcohol dehydrogenase superfamilies, reducing the need for high-throughput screening.

Tension sensing by FAK governs nuclear mechanotransduction, endothelial transcriptome and fate

This study shows that FAK-mediated tension sensing in endothelial cells regulates nuclear mechanotransduction, transcriptome, and cell fate, crucial for maintaining a restrictive endothelial barrier.

Comparative analysis of Glycine BBX gene family reveals lineage-specific evolution and expansion

This study compares the BBX gene family in Glycine max and Glycine soja to reveal lineage-specific evolution and expansion through segmental duplication and synteny.

Insights into cargo sorting by SNX32 in neuronal and non-neuronal cells: physiological implications in neurite outgrowth

This study identifies SNX32's role in cargo sorting via its PX and BAR domains, showing its involvement in transferrin trafficking and neuronal differentiation.

High resolution photocatalytic mapping of SARS-CoV-2 Spike protein-host cell membrane interactions

This study identifies additional host proteins involved in SARS-CoV-2 entry using a novel photocatalytic mapping platform called ViraMap.

Rational engineering of a β-glucosidase (H0HC94) from glycosyl family I (GH1) to improve catalytic performance on cellobiose

This paper rationally engineers a β-glucosidase to enhance its catalytic activity and specificity for cellobiose over pNPGlc.

RAV1 mediates cytokinin signalling for regulating primary root growth in Arabidopsis

This study identifies RAV1 as a transcription factor that mediates cytokinin signaling to regulate primary root meristem size in Arabidopsis by modulating auxin transport and CRF1 expression.

MicroProteins miP1b/BBX30 and miP1a/BBX31 form a positive feedback loop with ABI5 to retard seedling establishment

The paper identifies a positive feedback loop between ABI5 and microProteins miP1a/BBX31 and miP1b/BBX30 that delays seedling establishment under unfavorable conditions.

RICTOR Drives ZFX-mediated Ganglioside Biosynthesis to Promote Breast Cancer Progression.

This study identifies RICTOR's role in regulating ganglioside biosynthesis via ZFX and UGCG, promoting breast cancer progression through EGFR signaling.

A hold-and-feed mechanism drives directional DNA loop extrusion by condensin

This study reveals that condensin uses a hold-and-feed mechanism to extrude DNA loops bidirectionally by separating motor and anchor functions in distinct chambers.

The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium

This study identifies the exocyst complex and Rab GTPases as key factors in the trafficking of soluble proteins, such as Gli transcription factors, to the primary cilium.

ZeBox: A novel non-intrusivecontinuous-use technology to trap and killairborne microbes

ZeBox is a new air decontamination technology that uses an electric field and engineered surfaces to trap and kill airborne microbes efficiently and safely.

Flexibility of Short-chain dehydrogenase is interconnected to its promiscuity for the reduction of multiple ketone intermediates

The paper uses machine learning to identify promiscuous SDRs based on physicochemical properties, showing a correlation between C-terminal structure, melting temperature, and catalytic efficiency.

SUFFICIENT ACTIVITY OF THE UBIQUITIN PROTEASOME SYSTEM IN AGED MICE AND DURING RETINAL DEGENERATION SUPPORTS DHFR-BASED CONDITIONAL CONTROL OF PROTEIN ABUNDANCE IN THE RETINA

This study evaluates the effectiveness of a DHFR-based system for conditional protein control in aged and retinal degeneration mouse models, showing successful degradation despite compromised UPS in some models.

HDAC inhibitor Givinostat targets DNA-binding of human CGGBP1

The paper identifies Givinostat as a direct inhibitor of CGGBP1-DNA interaction, expanding its known mechanism beyond HDAC inhibition.

Detection of 'relict' western lineage of citrus tristeza virus virulent genotype in declining Arunachal Wakro orange

The paper identifies a relict western lineage of citrus tristeza virus virulent genotype VT in declining Arunachal Wakro orange orchards, distinct from other Indian and neighboring CTV sequences.

Novel mTORC1 inhibitors kill Glioblastoma stem cells

This paper identifies novel mTORC1 inhibitors that effectively kill GBM stem cells and shows their potential as adjuvant therapy when combined with temozolomide.

Snx14 proximity labeling reveals a role in saturated fatty acid metabolism and ER homeostasis defective in SCAR20 disease

This study identifies Snx14's role in maintaining lipid saturation and ER homeostasis, showing its deficiency leads to lipotoxicity and contributes to SCAR20 disease.

Maximization of non-nitrogenous metabolite production in E. coli using population systems biology

This paper develops a population systems biology algorithm to enhance non-nitrogenous metabolite production in E. coli by considering transcriptome diversity and introducing nitrogen-swap strategies.

Elucidating the regulation of glucose tolerance through the interaction between the reaction product and active site pocket residues of a β-glucosidase from Halothermothrix orenii

This study investigates how glucose interacts with a β-glucosidase from Halothermothrix orenii, showing that glucose enhances enzyme activity by increasing active site flexibility and substrate accessibility.

Excavating New Facts from Ancient Hepatitis B Virus Sequences

This study re-analyzes ancient Hepatitis B virus sequences to explore their relationship with modern HBV diversity and migration patterns.

Drosophila Snazarus regulates a lipid droplet population at plasma membrane-droplet contacts in adipocytes

This study identifies Snazarus as a regulator of lipid droplet organization in Drosophila adipocytes, showing its role in maintaining peripheral lipid droplets at plasma membrane contacts.