H. Peng

pH-Controlled chemoselective rapid azo-coupling reaction (CRACR) enables global profiling of serotonylation proteome in cancer cells

The paper develops a chemical proteomic method to globally profile serotonylation in cancer cells, identifying over 1,000 serotonylated proteins and their modification sites.

Chemical proteomic profiling of protein dopaminylation in colorectal cancer cells

The paper identifies 425 dopaminylated proteins in colorectal cancer cells using a chemical probe, revealing their involvement in nucleic acid metabolism and transcription, and suggests targeting protein dopaminylation as a potential anti-cancer strategy.

Bioorthogonal labeling and enrichment of histone monoaminylation reveal its accumulation and regulatory function in cancer cell chromatin

This study develops chemical probes to label and enrich histone monoaminylation, revealing its enrichment in cancer tissues and its role in chromatin architecture regulation.

Early cytokine-driven adaptation of survival pathways in lymphoid cells during targeted therapies

This study shows that CLL cells rapidly adapt to venetoclax by upregulating pro-survival proteins and cytokines, suggesting combination therapies targeting these pathways could improve treatment outcomes.

Systematic annotation of Helitron-like elements in eukaryote genomes using HELIANO

The paper introduces HELIANO, a tool for annotating Helitron-like elements in eukaryotic genomes, showing improved performance and identifying new elements across multiple species.

Comparative Metagenomics Provide Mechanistic Insights into the Biodegradation of the Non-hydrolysable Plastic Polyvinyl Chloride in Gut Microbiota of Insect Larvae

This study identifies a potent PVC-dechlorinating activity in gut microbiota of insect larvae using comparative metagenomics.

Bioconversion of Glucose-Rich Lignocellulosic Wood Hydrolysates to 3-Hydroxypropionic Acid and Succinic Acid using Engineered Saccharomyces cerevisiae

This study engineers Saccharomyces cerevisiae to produce 3-hydroxypropionic acid and succinic acid from glucose-rich lignocellulosic wood hydrolysates under low pH conditions, increasing production titers significantly.

DELLA Proteins Recruit the Mediator Complex Subunit MED15 to Co-activate Transcription in Land Plants

This paper identifies DELLA proteins as co-activators that recruit the Mediator subunit MED15 to facilitate transcription in land plants, showing conservation from Arabidopsis to liverworts.

ROCK1 activates mitochondrial fission leading to oxidative stress and muscle atrophy

This study identifies ROCK1 activation as a driver of mitochondrial fission and oxidative stress in CKD-induced muscle wasting, showing pharmacological inhibition of ROCK1 can alleviate these effects.

In vivo affinity maturation of murine B cells reprogrammed to express human antibodies

This study demonstrates that CRISPR-edited murine B cells expressing human antibodies can undergo affinity maturation, generating potent neutralizing antibodies against HIV-1 and SARS-CoV-2.

Chromosome-scale Genome Assembly of the Allopolyploid Arundo donax

This study presents two chromosome-scale genome assemblies of the allopolyploid plant Arundo donax, revealing its polyploid nature and evolutionary history through gene family expansion and whole-genome duplication events.

Antibody-mediated cell entry of SARS-CoV-2

This study shows that certain monoclonal antibodies can replace ACE2 to mediate SARS-CoV-2 entry into cells, indicating that ACE2 is not essential for viral infection.

Real-Time Quantification of Cell Mechanics and Functions by Double Resonator Piezoelectric Cytometry -Theory and Study of Cellular Adhesion of HUVECs

This paper introduces DRPC to measure cell-generated forces and viscoelastic moduli in real time, showing ligand and cell density affect mechanical properties of HUVECs.

Redistribution and activation of CD16brightCD56dim NK cell subset to fight against Omicron subvariant BA.2 after COVID-19 vaccination

This study shows that COVID-19 vaccination enhances the activation and redistribution of CD16brightCD56dim NK cells in Omicron BA.2-infected patients, improving clinical outcomes.

Cryo-EM structure of SARS-CoV-2 postfusion spike in membrane

The paper reports a cryo-EM structure of the SARS-CoV-2 postfusion spike in a membrane, revealing structural details of membrane-interacting segments.

Not just with the natives, but phylogenetic relationship between stages of the invasion process determines invasion success of alien plant species

The paper tests Darwin's hypotheses on alien plant invasion success by analyzing phylogenetic relationships across invasion stages and environmental contexts.

Pangenome-based dynamic trajectories of intracellular gene transfers in Poaceae unveil a high rate of unceasing integration and selective retention in Triticeae

This study maps the dynamic trajectories of intracellular gene transfers in Poaceae using a novel tool, revealing lineage-specific patterns and functional roles of nuclear organelle genes.

Structure of human phagocyte NADPH oxidase in the resting state

The paper reports the cryo-EM structure of the human NOX2-p22 complex in the resting state, revealing interactions and conformational features important for its function.

"Double-Effect" strategy against Triple-Negative Breast Cancer via a synergistic therapy of Magneto-mechanical Force enhancing NIR-II Hypothermal Ablation

This paper develops a synergistic therapy for triple-negative breast cancer using magneto-mechanical force and NIR-II hypothermal ablation to suppress tumor migration and invasion.

An mTOR-independent Macroautophagy Activator Ameliorates Tauopathy and Prionopathy Neurodegeneration Phenotypes

The paper identifies CCT020312, an mTOR-independent autophagy activator, which reduces tauopathy and prionopathy neurodegeneration phenotypes by enhancing autophagy flux and clearing protein aggregates.

Humanized antibody potently neutralizes all SARS-CoV-2 variants by a novel mechanism

The paper describes a humanized antibody, SP1-77, that neutralizes all SARS-CoV-2 variants by blocking membrane fusion instead of ACE2 receptor binding.

A genetically engineered phage-based nanomaterial for detecting bacteria with magnetic resonance imaging

This paper develops a genetically engineered phage-based nanomaterial for MRI detection of specific bacteria, demonstrating its ability to distinguish target strains from non-target bacteria and mammalian cells in vivo.

Structural and functional characteristics of SARS-CoV-2 Omicron subvariant BA.2 spike

This study characterizes the structural, functional, and antigenic properties of SARS-CoV-2 Omicron BA.2 spike protein and compares its replication efficiency with previous variants.

Structural and functional impact by SARS-CoV-2 Omicron spike mutations

This study examines the structural, functional, and antigenic properties of the SARS-CoV-2 Omicron spike protein, revealing its enhanced immune evasion and altered fusogenic capability due to mutations.

Treatment of wound infections in a mouse model using Zn2+-releasing phage bound to gold nanorods

This study shows that phage-nanomaterial conjugates effectively treat P. aeruginosa infections in mice by reducing bacterial load and promoting wound healing without toxicity.

HBV enveloped particle secretion is positively regulated by GRP78 through direct interaction with preS1

This study identifies GRP78 as a positive regulator of HBV enveloped-particle secretion through direct interaction with preS1, suggesting it as a potential therapeutic target.

Lateral plate mesoderm cell-based organoid system for NK cell regeneration from human pluripotent stem cells

This study develops an organoid-based method to generate large quantities of NK cells from human pluripotent stem cells without feeder cells, achieving efficient and scalable iNK cell production.

Polyvinyl Chloride Degradation by Intestinal Klebsiella of Pest larvae

The paper identifies a Klebsiella strain from the gut of Spodoptera frugiperda larvae that degrades PVC, using multi-omics to characterize the degradation pathway.

Membrane fusion and immune evasion by the spike protein of SARS-CoV-2 Delta variant

This study compares the structure, function, and antigenicity of the SARS-CoV-2 Delta variant's spike protein with other variants, showing its enhanced membrane fusion and transmissibility.

Regeneration of humoral immunity from pluripotent stem cells by defined transcription factors

This study regenerates functional B lymphopoiesis from pluripotent stem cells (PSCs) using Runx1, Hoxa9, and Lhx2, producing antigen-specific antibodies and immune memory in B-cell deficient animals.