Author

M. Rolland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 2 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1 Assay:structural biology· 1

Frequent Co-Authors

H. Bai· 3 shared M. G. Joyce· 3 shared E. Lewitus· 2 shared K. Modjarrad· 2 shared M. Amare· 2 shared N. L. Michael· 2 shared P. Scott· 2 shared S. Vasan· 2 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersMicrobiology

H. Bai

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Contemporary HIV-1 consensus Env with redesigned hypervariable loops promote antibody binding

H. Bai, E. Lewitus, Y. Li, V. Dussupt, B. Slike, L. Mendez-Rivera, A. Schmid, L. Wieczorek, V. Polonis, S. J. Krebs, J. A. Ake, S. Vasan, M. G. Joyce, S. Townsley, M. Rolland

The paper redesigns hypervariable loops in HIV-1 Env consensus sequences to enhance antibody binding and improve vaccine antigen design.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains

B. L. Dearlove, E. Lewitus, H. Bai, Y. Li, D. B. Reeves, M. G. Joyce, P. Scott, M. Amare, S. Vasan, N. L. Michael, K. Modjarrad, M. Rolland

The paper analyzes SARS-CoV-2 sequence diversity and finds limited variation in the Spike protein, suggesting a single vaccine could be effective against current strains.

bioRxiv · Apr 27, 2020Evolutionary Biology

A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein

M. G. Joyce, R. S. Sankhala, W.-H. Chen, M. Choe, H. Bai, A. Hajduczki, L. Yan, S. L. Sterling, C. Peterson, E. C. Green, C. Smith, N. de Val, M. Amare, P. Scott, E. D. Laing, , K. Modjarrad

The paper reports the high-resolution structure of the SARS-CoV-2 Spike RBD and identifies a conserved epitope accessible in open conformations, which is targeted by cross-reactive antibodies.

bioRxiv · Mar 15, 2020 · PreprintImmunology

HIV population-level adaptation can rapidly diminish the impact of a partially effective vaccine

J. Herbeck, K. Peebles, P. Edlefsen, M. Rolland, J. Murphy, G. Gottlieb, N. Abernethy, J. Mullins, J. Mittler, S. Goodreau

This study shows that HIV can adapt rapidly to partially effective vaccines, reducing their impact and increasing new infections in vaccinated populations.

bioRxiv · Feb 22, 2017Evolutionary Biology