L. Yan

Megabarcoding reveals a tale of two very different dark taxa along the same elevational gradient

The paper uses megabarcoding to show that two Diptera taxa have distinct spatio-temporal distributions along an elevational gradient in a temperate forest.

ZNF574 is a Quality Control Factor For Defective Ribosome Biogenesis Intermediates

The paper identifies ZNF574 as a key factor in a quality control pathway that degrades defective ribosome intermediates in human cells.

Modulation of photosystem II heterogeneity and stomatal functioning contribute to sustaining photochemistry and photoprotection in mangroves exposed to a cold wave

This study investigates how PSII heterogeneity and stomatal functioning help mangroves withstand cold waves, finding that cold-tolerant species show less impact due to local adaptations.

The Genomes of Nematode-Trapping Fungi Provide Insights into the Origin and Diversification of Fungal Carnivorism

This study compares the genomes of nematode-trapping fungi and non-NTF to identify genomic changes linked to carnivorism and adaptation to post-Permian-Triassic extinction environments.

Granzyme B-based CAR T cells block metastasis by eliminating circulating tumor cells

This study develops GrB-CAR T cells targeting mHSP70 to eliminate CTCs and inhibit metastasis in solid tumors.

Olfaction foraging in visually oriented tropical arboreal ants Oecophylla smaragdina: Implications for insect predation studies using artificial sentinel prey

This study tests the effectiveness of sentinel prey in identifying predators by showing that Oecophylla smaragdina ants rely more on olfactory cues than visual cues for predation.

Structure and design of Langya virus glycoprotein antigens

The paper determines the structure of Langya virus glycoproteins and shows they use a different receptor than NiV and HeV, with no cross-reactivity of antibodies.

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

Comprehensive characterization of tumor microenvironment in colorectal cancer via histopathology-molecular analysis

This study characterizes the tumor microenvironment in colorectal cancer using multi-omics and spatial analysis, identifying four subtypes with distinct features and therapeutic responses.

LINC01184 is highly expressed and functions as a tumor-promotive factor in hepatocellular carcinoma

This study identifies LINC01184 as a tumor-promotive factor in hepatocellular carcinoma, showing its overexpression correlates with poor patient outcomes and its role in promoting cell proliferation and migration.

LINC02428, a liver-specific long noncoding RNA suppresses hepatocellular carcinoma progression

This study identifies LINC02428 as a liver-specific lncRNA that suppresses hepatocellular carcinoma progression by inhibiting cell proliferation, migration, and inducing apoptosis.

DOTA chelation through click chemistry enables favorable biodistribution of 89Zr-radiolabeled antibodies: A comparison with DFO chelation

This paper compares the biodistribution of 89Zr-labeled antibodies conjugated with DOTA versus DFO chelators, finding that DOTA chelation via click chemistry provides better biodistribution profiles.

Processing Stage Flexibility of the SNARC effect: Task Relevance or Magnitude Relevance?

This study investigates the SNARC effect's processing stage flexibility by comparing magnitude and parity Stroop effects across tasks, finding magnitude-relevant interference information primarily influences the SNARC effect.

Rhamnan Sulfate Reduces Atherosclerotic Plaque Formation and Vascular Inflammation

This study shows rhamnan sulfate reduces atherosclerosis and vascular inflammation in ApoE-/- mice by enhancing endothelial barrier function and inhibiting NF-κB pathway activation.

Differential viral RNA methylation contributes to pathogen blocking in Wolbachia-colonized arthropod

This study shows that Wolbachia reduces viral RNA methylation via DNMT2 suppression, inhibiting alphavirus replication and transmission.

Groundwater bacterial communities evolve over time, exhibiting oscillating similarity patterns in response to recharge

The paper analyzes groundwater bacterial communities over six years to show they change with recharge events, becoming more dissimilar over time.

Phospholipase A2 inhibitor-loaded micellar nanoparticles attenuate inflammation and mitigate osteoarthritis progression

This study develops sPLA2 inhibitor-loaded micellar nanoparticles that reduce inflammation and slow osteoarthritis progression in human and mouse models.

Targeting glucose metabolism sensitizes pancreatic cancer to MEK inhibition

This study shows that combining glucose metabolism inhibition with MEK inhibition enhances apoptosis in pancreatic cancer cells by inducing ER stress.

First demonstration of the FLASH effect with ultrahigh dose-rate high-energy X-rays

This paper demonstrates the first use of high-energy X-rays in FLASH radiotherapy, showing effective tumor control and tissue protection in mice.

Hyaluronic Acid Fuels Pancreatic Cancer Growth

This study shows hyaluronic acid fuels pancreatic cancer metabolism by bypassing GFAT1 via the GlcNAc salvage pathway, enabling proliferation in nutrient-starved conditions.

Molecular evolution of SARS-CoV-2 structural genes: evidence of positive selection in spike glycoprotein

This study identifies positive selection in the SARS-CoV-2 spike gene, particularly the D614G mutation, which may enhance viral entry and adaptability during the pandemic.

Differential responses of antioxidants and dehydrin expression in two switchgrass (Panicum virgatum) cultivars contrasting in drought tolerance

This study compares antioxidant enzyme activity, dehydrin expression, and gene expression in two switchgrass cultivars under drought stress to identify markers of drought tolerance.

Structure of RNA-dependent RNA polymerase from 2019-nCoV, a major antiviral drug target

The paper reports the cryo-EM structure of 2019-nCoV RdRp complexed with cofactors, revealing key residues and remdesivir binding, aiding antiviral drug design.

A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein

The paper reports the high-resolution structure of the SARS-CoV-2 Spike RBD and identifies a conserved epitope accessible in open conformations, which is targeted by cross-reactive antibodies.

The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice

This study infects hACE2 transgenic mice with SARS-CoV-2 and observes pathogenic effects, confirming Koch's postulates and establishing a model for vaccine and therapeutic development.

Boron alters carboxyl group binding capacity and Al transport pathway to relieve Al toxicity

Boron reduces Al binding to pectin carboxyl groups, decreases cytoplasmic Al deposition, and compartmentalizes Al into vacuoles, thereby alleviating Al toxicity in plants.

Cyniclomyces guttulatus is an opportunistic pathogen in rabbits with coccidiosis

This study isolates and characterizes Cyniclomyces guttulatus from diarrheic rabbits, showing it is not pathogenic alone but can exacerbate coccidiosis when co-inoculated with Eimeria intestinalis.

YAP1 Oncogene is a Context-specific Driver for Pancreatic Ductal Adenocarcinoma

This study identifies YAP1 as a context-specific driver for the squamous subtype of pancreatic ductal adenocarcinoma and shows WNT5A promotes tumor progression through YAP1 activation.

Mechanics of allostery: contrasting the induced fit and population shift scenarios

The paper investigates allosteric conformational changes in proteins, finding that a soft elastic mode with high shear is common, and that cooperativity depends on stiffness and protein size.

Phanerochaete chrysosporium strain B-22, a parasitic fungus infecting Meloidogyne incognita

This study characterizes the parasitic effect of Phanerochaete chrysosporium strain B-22 on Meloidogyne incognita life stages and demonstrates its efficacy as a biocontrol agent for tomato plants.