P. Scott

Malnutrition disrupts adaptive immunity during visceral leishmaniasis by enhancing IL-10 production

This study shows malnutrition worsens visceral leishmaniasis by impairing IFN-γ immunity and boosting IL-10, which is reversed by IL-10R blockade.

CCR5 promotes the migration of CD8+ T cells to the leishmanial lesions

This study identifies CCR5 as a key mediator of CD8+ T cell migration to leishmanial lesions, showing that blocking CCR5 reduces lesion severity without affecting parasite load.

Sequentially activated death complexes regulate pyroptosis and IL-1β release in response to Yersinia blockade of immune signaling

This study shows that Yersinia-induced cell death and IL-1β release are driven by spatially and temporally distinct but functionally connected death complexes.

Persistence of SARS CoV-2 S1 Protein in CD16+ Monocytes in Post-Acute Sequelae of COVID-19 (PASC) Up to 15 Months Post-Infection

This study finds SARS-CoV-2 S1 protein in non-classical monocytes in PASC patients up to 15 months post-infection, but not full-length viral RNA.

Microbiota instruct IL-17A-producing innate lymphoid cells to promote skin inflammation in cutaneous leishmaniasis

This study shows that skin microbiota promotes IL-17A-producing RORγt+ ILCs, which drive inflammation in cutaneous leishmaniasis.

Increased and ectopic expression of Triticum polonicum VRT-A2 underlies elongated glumes and grains in hexaploid wheat in a dosage-dependent manner

An intron-1 rearrangement in the MADS-box transcription factor VRT-A2 leads to its misexpression and defines the long-glume phenotype of Polish wheat (T. polonicum).

Defining the early stages of intestinal colonisation by whipworms

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains

The paper analyzes SARS-CoV-2 sequence diversity and finds limited variation in the Spike protein, suggesting a single vaccine could be effective against current strains.

A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein

The paper reports the high-resolution structure of the SARS-CoV-2 Spike RBD and identifies a conserved epitope accessible in open conformations, which is targeted by cross-reactive antibodies.