Computational design of highly signaling active membrane receptors through de novo solvent-mediated allosteric networks
M. Chen, J. Lai, J. Wang, K. Conners, A. Russell, E. Hembre, M. Rutter, B. Condon, L. Kodandapani, B. Chau, X. Zhao, J. Benach, K. Baker, P. Barth
This paper designs novel membrane receptors with enhanced activity and stability through engineered allosteric networks involving solvent-mediated interactions.
bioRxiv · Sep 29, 2021 · PreprintBiophysics