BiochemistrybioRxiv
Determining the defining lengths between mature microRNAs/small interfering RNAs and tinyRNAs
G. Sim, A. C. Kehling, M. S. Park…·K. Nakanishi
The paper determines the minimum guide lengths required for miR-20a and let-7a to maintain their RISC conformation, finding 19 and 20 nt respectively, and identifies 17-nt guides as functional tinyRNAs (tyRNAs) without PAZ domain anchoring.
DOI 10.1038/s41598-023-46562-6