Phosphorylation of the M1 muscarinic acetylcholine receptor mediates protection in neurodegenerative disease
M. Scarpa, C. Molloy, L. Jenkins, G. S. Tejeda, M. Rossi, L. Dwomoh, S. Marsango, Z. Ahmed, G. Milligan, B. D. Hudson, A. B. Tobin, S. J. Bradley
This study shows that phosphorylation and arrestin-dependent signaling of the M1 muscarinic receptor provides neuroprotection in prion disease, suggesting potential for developing safer therapies for neurodegenerative diseases.
bioRxiv · Apr 29, 2021 · PreprintPharmacology & Toxicology