Z. Ahmed

This paper develops a hydrogel that delivers doxorubicin and sodium bicarbonate to neutralize tumor acidity and enhance chemotherapy efficacy.

This study investigates SMII filament dynamics in vascular smooth muscle cells, showing they are dynamic and stabilize during contraction, with implications for vascular regulation and disease.

This study shows that RTKs form liquid-liquid phase-separated states with downstream effectors to enhance signaling fidelity.

This study shows that phosphorylation and arrestin-dependent signaling of the M1 muscarinic receptor provides neuroprotection in prion disease, suggesting potential for developing safer therapies for neurodegenerative diseases.

The paper investigates how juxtamembrane and C-terminal regions regulate kinase activity in RTKs, identifying key interactions and mutations linked to disease.

This study shows Grb2 binding activates Shp2 independently of phosphorylation, and identifies a peptide that blocks this interaction, reducing Shp2 activity and MAPK signaling.

The paper uses simulations to study how tumor growth dynamics and cell turnover affect intratumor heterogeneity and circulating tumor cell cluster diversity, finding that modest changes in growth parameters can significantly increase diversity.