Control of alveolar macrophage differentiation by Siah1a/2 ubiquitin ligases limits carcinogen-induced lung adenocarcinoma
M. Scortegagna, Y. Du, L. M. Bradley, K. Wang, E. Ruppin, R. Murad, Z. A. Ronai
This study shows that Siah1a/2 ubiquitin ligases regulate alveolar macrophage differentiation, and their loss promotes lung adenocarcinoma by increasing immature macrophages and pro-tumorigenic inflammation.
bioRxiv · Sep 14, 2022Cancer Biology