M. Slak Rupnik

This study measures Ca2+ dynamics in beta cell collectives using high-resolution imaging and a new computational framework, revealing three modes of Ca2+ event durations and the role of intracellular Ca2+ receptors.

This study investigates glucose-dependent changes in beta cell network activity in mouse pancreas tissue slices, revealing heterogeneity and functional connectivity patterns during activation, activity, and deactivation.

The paper demonstrates that beta cells use collective communication to maintain glucose homeostasis through gap-junctional signaling and paracrine interactions, supported by a dynamical network model and empirical data analysis.