M. Sousa

Perivascular cells function as mechano-structural sensors of vascular capillaries

This study shows perivascular cells sense mechanical changes in collagen matrix, affecting vascular function and contributing to fibrotic conditions.

Dopamine neurons encode a multidimensional probabilistic map of future reward

This study introduces time-magnitude RL (TMRL), a new reinforcement learning framework, and shows that dopamine neurons encode a probabilistic map of future rewards in mice.

Long-term mitotic DNA damage promotes chromokinesin-mediated missegregation of polar chromosomes in cancer cells

The paper shows that long-term mitotic DNA damage in cancer cells leads to chromokinesin-mediated missegregation of polar chromosomes via stabilized kinetochore-microtubule attachments.

Extended bacterial diversity of the urinary microbiome of reproductive-age healthy European women captured by culturomics and long-read amplicon sequencing

This study characterizes the urinary microbiome of healthy European women using culturomics and long-read sequencing, revealing high species diversity and inter-individual variation.

A 21-year survey of Escherichia coli from bloodstream infections (BSIs) in a tertiary hospital reveals how community-hospital dynamics of the B2 phylogroup clones influence local BSI rates

This study analyzes 21 years of E. coli bloodstream infections in a hospital, showing how community and hospital dynamics of B2 phylogroup clones influence BSI rates.

The mutability of demographic noise in microbial range expansions

This study measures how single gene deletions in E. coli affect demographic noise during range expansions, finding that mutations can reduce noise and enhance beneficial mutation establishment.

Worldwide recombination in emergent white-nose syndrome pathogen Pseudogymnoascus destructans

This study detects recombination in the clonal fungus Pseudogymnoascus destructans using clone-corrected linkage disequilibrium analysis, revealing sexual reproduction in European populations and parasexual recombination in North American populations.

Coherent-hybrid STED: a tunable photo-physical pinhole for super-resolution imaging at high contrast

This paper introduces CH-STED, a super-resolution imaging technique that improves optical sectioning and reduces background fluorescence for high-contrast imaging of biological structures.