S. Aoki

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule-associated protein Tau

This study identifies Praja1 as an E3 ligase that ubiquitinates and degrades Tau, a key protein in tauopathies, and shows evolutionary conservation of this interaction.

Nationwide genome surveillance of carbapenem-resistant Pseudomonas aeruginosa in Japan

This study analyzes genome sequences and antimicrobial resistance patterns of carbapenem-resistant Pseudomonas aeruginosa isolates from Japan, revealing genetic diversity and lower multidrug resistance prevalence compared to other regions.

Scalable phylogenetic Gaussian process models improve the detectability of environmental signals on extinction risks for many Red List species

This study develops a scalable phylogenetic Gaussian process model to better detect environmental signals on extinction risks for Red List species.

Reprogramming Intrahepatic Cholangiocarcinoma Immune Microenvironment by Chemotherapy and CTLA-4 Blockade Enhances Anti-PD1 Therapy

This paper shows that combining chemotherapy with CTLA-4 blockade reprograms the immune microenvironment of intrahepatic cholangiocarcinoma, enhancing the effectiveness of anti-PD1 therapy.

Characterization of HcaA, a novel autotransporter protein in Helicobacter cinaedi, and its role in host cell adhesion

This study identifies HcaA, a novel autotransporter protein in H. cinaedi, as critical for host cell adhesion and bacterial colonization through its RGD motif.

A fungal secondary metabolism gene cluster enables mutualist-pathogen transition in root endophyte Colletotrichum tofieldiae

The paper identifies a fungal gene cluster in Colletotrichum tofieldiae that enables lifestyle transition between mutualism and pathogenesis by modulating host nutrient uptake and ABA pathways.

IFNA pathway drives the more aggressive phenotype of KRASG12D-mutant pancreatic ductal adenocarcinomas via IFNAR1/STAT3 activation

The paper shows that the IFNA pathway promotes aggressive KRASG12D-mutant pancreatic ductal adenocarcinomas through IFNAR1/STAT3 activation and identifies IFNAR1 inhibition as a potential therapeutic strategy.

Defensive nymphs in the water-repellent gall of the social aphid Colophina monstrifica (Hemiptera: Aphididae: Eriosomatinae)

The paper describes the induction of galls by the aphid Colophina monstrifica on Zelkova serrata and documents defensive behaviors of nymphs against moth larvae.

Anti-severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) potency of Mefloquine as an entry inhibitor in vitro

This study identifies Mefloquine as a potent in vitro entry inhibitor of SARS-CoV-2 with higher antiviral activity than Hydroxychloroquine.

Multidrug treatment with nelfinavir and cepharanthine against COVID-19

This study identifies a new multidrug combination treatment for COVID-19 using nelfinavir and cepharanthine, showing synergistic antiviral effects and improved disease control.

Massive rhizobial genomic variations associated with partner quality in Lotus-Mesorhizobium symbiosis

The paper investigates how genetic variations in rhizobial symbionts affect partner quality in Lotus-Mesorhizobium symbiosis, finding that core genome variations, not symbiosis island genes, correlate with plant growth phenotypes.