Tension sensing by FAK governs nuclear mechanotransduction, endothelial transcriptome and fate
M. Z. Akhter, P. Yazbeck, M. Tauseef, M. Anwar, F. Hossen, S. Datta, V. Vellingiri, J. C. Joshi, N. Srivastava, S. Lenzini, G. Zhou, J. Lee, M. K. Jain, J.-W. Shin, D. Mehta
This study shows that FAK-mediated tension sensing in endothelial cells regulates nuclear mechanotransduction, transcriptome, and cell fate, crucial for maintaining a restrictive endothelial barrier.
bioRxiv · Apr 24, 2023 · PreprintCell Biology