Cell BiologybioRxiv
Longitudinal dynamics of clonal hematopoiesis identifies gene-specific fitness effects
N. A. Robertson, E. Latorre-Crespo, M. Terrada-Terradas…·T. Chandra
This study quantifies gene-specific fitness effects of CHIP drivers over 12 years using longitudinal sequencing data and a new DIF filtering method, showing gene-specific differences can inform personalized clinical management.
DOI 10.1038/s41591-022-01883-3