CDK12 controls transcription at damaged genes and prevents MYC-induced transcription-replication conflicts
L. Curti, S. Rohban, N. Bianchi, O. Croci, A. Andronache, S. Barozzi, M. Mattioli, F. Ricci, E. Pastori, s. Sberna, S. Bellotti, A. Accialini, r. Ballarino, N. Crosetto, M. Wade, , s. campaner
This study shows CDK12 prevents transcription-replication conflicts and DNA damage in MYC-overexpressing cells by repressing transcription at damaged genes.
bioRxiv · Jun 3, 2024Cancer Biology