A. Wei

A ubiquitous Streptomyces biosynthetic megacluster encodes an arsenal of synergistic biotin-targeting antibiotics

The paper identifies a conserved Streptomyces biosynthetic megacluster producing biotin-targeting antibiotics, effective against multidrug-resistant E. coli.

ASXL1 mutations that cause Bohring Opitz Syndrome (BOS) or acute myeloid leukemia share epigenomic and transcriptomic signatures

This study compares epigenomic and transcriptomic changes in Bohring-Opitz Syndrome and AML with ASXL1 mutations, finding shared dysregulation and potential common therapeutic targets.

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression via GTP

This paper identifies a non-canonical, methyltransferase-independent mechanism by which EZH2 promotes melanoma progression through interactions with IMPDH2 and GTP synthesis.

Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

The paper shows that inhibiting HDACs in AML promotes type I IFN production by pDCs, enhancing anti-tumor immunity and therapeutic benefit.

Quantifying Color Vision Changes Associated with Cataracts Using Cone Contrast Thresholds

This study quantifies color vision changes in cataract patients and aging individuals using cone contrast thresholds, finding age-related declines in S-cone sensitivity and improvements post-surgery.

Two-Photon Microperimetry: A media opacity-independent retinal function assay

This study evaluates 2-photon infrared microperimetry for assessing retinal function in patients with optical media opacities, finding it provides more consistent results than visible light methods.

Identification of microRNA-target interactions for antioxidant defense response under drought stress by high-throughput sequencing in Zanthoxylum bungeanum Maxim.

Drought Affects the Antioxidant System and Stomatal Aperture in Zanthoxylum bungeanum Maxim.

This study examines how drought affects the antioxidant system and stomatal aperture in Zanthoxylum bungeanum by analyzing enzyme activities, gene expression, and stomatal changes under drought conditions.