Potent, Gut-Restricted Inhibitors of Divalent Metal Transporter 1 (DMT1): Preclinical Efficacy Against Iron Overload and Safety Evaluation
A. J. Cutts, S. Chowdhury, L. Ratkay, M. Eyers, C. Young, R. Namdari, J. Cadieux, N. Chahal, M. Grimwood, Z. Zhang, S. Lin, I. Tietjen, Z. Xie, L. Robinette, L. Sojo, , C. J. Cohen
This paper identifies XEN602, a potent, gut-restricted DMT1 inhibitor, showing efficacy in reducing iron overload in rats and pigs with minimal systemic exposure.
bioRxiv · Sep 1, 2022Pharmacology & Toxicology