Molecular BiologybioRxivPreprint
A unique lower X-gate in TASK channels traps inhibitors within the vestibule
Karin E. J. Rödström, Aytuğ K. Kiper, Wei Zhang…·Elisabeth P. Carpenter
This paper reveals the structure of TASK-1 channels, identifying a unique lower X-gate that traps inhibitors in the vestibule, explaining their slow washout and pharmacological properties.