Cell BiologyBiology OpenPeer-reviewed
Disrupting the interaction between AMBRA1 and DLC1 is a promising therapeutic strategy for neurodegeneration that prevents apoptosis while enhancing autophagy and mitophagy
Kate Hawkins, Meg Watt, Sébastien Gillotin…·Janet Brownlees
The paper investigates AMBRA1 mutants to identify strategies that prevent apoptosis and enhance autophagy/mitophagy in neurodegeneration, finding that AMBRA1TAT, which disrupts DLC1 interaction, shows the most promise.