Cancer BiologybioRxivPreprint
Targeting MTHFD2 disrupts mitochondrial redox homeostasis and restores venetoclax sensitivity in acute myeloid leukemia
Judith O. Sokei, Orsola di Martino, Mary Basse…·Stephen Matthew Sykes
This study identifies MTHFD2 as a critical mitochondrial enzyme in AML that supports redox homeostasis and therapeutic resistance, showing that its inhibition restores venetoclax sensitivity.