Mary Hongying Cheng

The paper identifies NCOA7's role in lysosomal function and inflammatory sterol metabolism in PAH, showing its deficiency exacerbates disease through oxysterol/bile acid generation.

The paper determines the cryo-EM structure of the CMKLR1-Gi complex with chemerin9, revealing molecular mechanisms of signaling and potential for small molecule agonist development.

This study reports the cryo-EM structure of VMAT2 bound to tetrabenazine, revealing its inhibition mechanism and conformational dynamics.

This paper shows that phosphorylation of Syntaxin1 at Ser14 is critical for non-vesicular dopamine release and AMPH-induced behaviors in Drosophila.

This study investigates how bile acid obeticholic acid (OCA) interacts with the dopamine transporter (DAT) and modulates its activity through non-competitive binding mechanisms.

This study investigates the effects of a DAT mutation linked to DTDS, showing impaired dopamine function and behavioral deficits in Drosophila, with potential therapeutic implications.

Modeling indicates N501Y strengthens ACE2 binding while K417N and E484K break two interface salt bridges, leaving 501.V2 affinity near wildtype but weakening several monoclonal antibodies.