Cell BiologybioRxivPreprint
TECPR1 provides E3-ligase like activity to the ATG5-ATG12 complex to conjugate LC3/ATG8 to damaged lysosomes
Yingxue Wang, Matthew Jefferson, Matthew Whelband…·Thomas Wileman
This study shows TECPR1 can substitute for ATG16L1 to conjugate LC3 to damaged lysosomes by providing E3-ligase activity to the ATG5-ATG12 complex.
DOI 10.1101/2023.06.24.546289