Thomas E. Wileman

This study shows that PIKfyve inhibition leads to LRRK2 hyperactivation through PI3P and CASM, revealing a new mechanism involving membrane lipids and Rab proteins.

This study investigates the role of Atg16l1 in skin homeostasis using LAP-deficient mice, finding no significant cutaneous phenotype despite histological differences.

This study identifies the V-ATPase-ATG16L1 axis as a mechanism recruiting LRRK2 to stressed lysosomes, facilitating lysosomal stress responses independent of canonical autophagy.

The paper uses transcriptomics and network analysis to study regulatory networks in Paneth and goblet cell enriched gut organoids, identifying key regulators and their links to inflammatory bowel disease.

The paper integrates proteomic and transcriptomic data from intestinal organoids to identify autophagy-dependent processes in Paneth cells, showing that autophagy impairment affects protein abundance and key cellular functions.