BioengineeringStem Cell ReportsPeer-reviewed
ER stress and lipid imbalance drive embryonic cardiomyopathy in a human heart organoid model of pregestational diabetes
Aleksandra S. Kostina, Yonatan R. Lewis‐Israeli, Mishref Abdelhamid…·Aitor Aguirre
This study uses human heart organoids to show that pregestational diabetes causes ER stress and lipid imbalance, leading to cardiomyopathy, and identifies potential therapeutic targets.