BiophysicsbioRxivPreprint
Stacked binding of a small molecule PET tracer to Alzheimer's tau paired helical filaments
G. E. Merz, M. J. Chalkley, S. K. Tan…·D. R. Southworth
The paper determines the cryo-EM structure of GTP-1 bound to Alzheimer's tau filaments, revealing a stacked binding arrangement and favorable pi-pi interactions.