Rtt105 configurationally staples RPA and blocks facilitated exchange and interactions with RPA-interacting proteins
S. Kuppa, J. Deveryshetty, R. Chadda, J. Mattice, N. Pokhrel, V. Kaushik, A. Patterson, N. Dhingra, S. Pangeni, M. K. Sadauskas, S. Shiekh, H. Balci, T. Ha, X. Zhao, B. Bothner, E. Antony
This study shows Rtt105 binds to RPA, staples it, and blocks RIP interactions without ssDNA, while stabilizing RPA-ssDNA filaments with ssDNA.
bioRxiv · Feb 5, 2022 · PreprintBiochemistry