Mild SARS-CoV-2 infection in rhesus macaques is associated with viral control prior to antigen-specific T cell responses in tissues
C. E. Nelson, S. Namasivayam, T. W. Foreman, K. D. Kauffman, S. Sakai, D. E. Dorosky, N. E. Lora, NIAID/DIR Tuberculosis Imaging Program, K. Brooks, E. L. Potter, M. Roederer, A. Sher, D. Weiskopf, A. Sette, E. de Wit, , D. L. Barber
This study shows that SARS-CoV-2 replication declines in the lungs before T cell responses, while innate immunity restricts viral replication in nasal and oral mucosa in rhesus macaques.
bioRxiv · Jan 6, 2022Immunology