Author

N. E. Sealover

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. L. Kortum· 4 shared A. J. Linke· 3 shared P. L. Theard· 3 shared B. R. Daley· 2 shared J. M. Hughes· 2 shared K. Cox· 2 shared B. Daley· 1 shared C. Rao· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersCancer Biology

R. L. Kortum

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4 papers

Recent·Most cited

Cancer BiologybioRxivJan 27, 2023

In situ modeling of acquired resistance to RTK/RAS pathway targeted therapies

N. E. Sealover, P. L. Theard, J. M. Hughes…·R. L. Kortum

This paper introduces an in situ resistance assay to model acquired resistance to RTK/RAS pathway targeted therapies and shows SHP2 inhibitors can delay resistance development.

DOI 10.1016/j.isci.2023.108711

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivJan 20, 2023

SOS2 regulates the threshold of mutant EGFR-dependent oncogenesis

P. L. Theard, A. J. Linke, N. E. Sealover…·R. L. Kortum

This study shows SOS2 modulates EGFR-PI3K signaling threshold, affecting osimertinib efficacy and resistance in lung adenocarcinoma.

DOI 10.1002/1878-0261.13564

humanexperimental assay

𝕏 PostBluesky

Cancer BiologybioRxivDec 6, 2022

SOS1 and KSR1 modulate MEK inhibitor responsiveness to target resistant cell populations based on PI3K and KRAS mutation status

B. Daley, H. M. Vieira, C. Rao…·R. L. Kortum

This study shows that targeting SOS1 or KSR1 enhances MEK inhibitor efficacy and prevents resistance in KRAS-mutated cancers, depending on specific KRAS and co-mutation status.

DOI 10.1073/pnas.2313137120

humanbulk RNA-seq

𝕏 PostBluesky

Cancer BiologybioRxivApr 28, 2020

Marked Synergy by Vertical Inhibition of EGFR signaling in NSCLC Spheroids: SOS1 as a therapeutic target in EGFR-mutated cancer

P. L. Theard, E. Sheffels, N. E. Sealover…·R. L. Kortum

The paper shows that inhibiting SOS1 synergizes with EGFR-TKIs in 3D spheroids of EGFR-mutated NSCLC, enhancing signaling pathway inhibition.

DOI 10.7554/elife.58204

humanbulk RNA-seq

𝕏 PostBluesky