S. Schmidt

The neuropeptide alpha calcitonin gene-related peptide impairs load-stimulated proteoglycan production of human chondrocytes via WNT activity

This study shows that CGRP impairs load-stimulated proteoglycan production in human chondrocytes by modulating WNT activity, suggesting a new therapeutic target for osteoarthritis.

Protein fusion strategies for a multi-component Rieske oxygenase

This study evaluates protein fusion strategies to simplify the multi-component electron transfer chain of a Rieske oxygenase, showing that fusing CDO-Red to CDO-Fd enables efficient oxygenase activation and product formation.

Recombinant manufacturing of multispecies biolubricants

This study develops recombinant lubricin analogs with improved biocompatibility and lubricating properties, demonstrating their tissue binding and joint retention in rats.

Label-free Assessment of Complement-Dependent Cytotoxicity of Therapeutic Antibodies via a Whole-Cell MALDI Mass Spectrometry Bioassay

This study develops a label-free MALDI-TOF mass spectrometry bioassay to assess complement-dependent cytotoxicity of Rituximab, identifying metabolite markers and demonstrating robust concentration-response characteristics.

Enhanced metabolic entanglement emerges during the evolution of an interkingdom microbial community

This study evolves an engineered microbial community to show how metabolic interactions increase, leading to interdependence and indirect selection for mutualism.

Mesenchymal stromal cell chondrogenesis under ALK1/2/3-specific BMP inhibition: A revision of the prohypertrophic signalling network concept

This study investigates the role of ALK1/2/3 inhibition in mesenchymal stromal cell chondrogenesis, finding that BMP-ALK1/2/3 signaling is not a driver of hypertrophy and that PTHrP/hedgehog and WNT signaling are more critical in hypertrophic differentiation.

Protein aggregation is a consequence of the dormancy-inducing membrane toxin TisB in Escherichia coli

This study shows that the membrane toxin TisB in E. coli causes protein aggregation, which enhances cellular dormancy and antibiotic tolerance.

Developing Hybrid Systems to Address O2 Uncoupling in Multi-Component Rieske Oxygenases

This study investigates O2 uncoupling in multi-component Rieske oxygenases by testing hybrid systems to reduce H2O2 formation and enhance catalytic efficiency.

Cause and chondroprotective effects of prostaglandin E2 secretion during mesenchymal stromal cell chondrogenesis

This study investigates the role of PGE2 in MSC chondrogenesis, showing it has chondroprotective effects despite being driven by prohypertrophic signals.

Image-Based Recognition of Parasitoid Wasps Using Advanced Neural Networks

The paper presents a neural network approach for image-based classification of parasitoid wasps, achieving 96% accuracy in species and sex classification.

Single-cell analysis reveals lasting immunological consequences of influenza infection and respiratory immunisation in the pig lung

This study uses single-cell RNA sequencing and flow cytometry to analyze immunological changes in pig lungs after influenza infection or vaccination, revealing lasting effects on immune cell populations and function.

Deep MALDI-MS Spatial Omics guided by Quantum Cascade Laser Mid-infrared Imaging Microscopy

This paper introduces a method combining quantum cascade laser infrared imaging with mass spectrometry to improve molecular identification in spatial omics, achieving high-resolution lipidomics profiling.

The unique Legionella longbeachae capsule favors intracellular replication and immune evasion

This study identifies a unique capsule in Legionella longbeachae that enhances intracellular replication and immune evasion, distinguishing it from other Legionella species.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

This study identifies RNF146 as an E3 ubiquitin ligase that degrades TEAD proteins via the proteasome, showing that pharmacological induction of TEAD ubiquitination can suppress YAP/TAZ-driven cancer growth.

Untargeted Metabolomics to Expand the Chemical Space of the Marine Diatom Skeletonema marinoi

This study uses untargeted metabolomics to expand the known chemical space of the marine diatom Skeletonema marinoi, identifying 1970 metabolites and highlighting their ecological and biotechnological significance.

Spatial omics imaging of fresh-frozen tissue and routine FFPE histopathology on a single cancer needle core biopsy: freezing device and multimodal workflow

The paper develops a device and workflow for multimodal spatial omics analysis of fresh-frozen and FFPE-processed needle biopsy cores to enable simultaneous molecular and histopathological analysis of cancer tissue.

The Kelch13 compartment is a hub of highly divergent vesicle trafficking proteins in malaria parasites

The paper identifies novel proteins in the K13 compartment of malaria parasites and shows they are involved in endocytosis and ART resistance, with some showing unique domain structures.

3D-Mass Spectrometry Imaging of Micro-scale 3D Cell Culture Models in Cancer Research

The paper presents a 3D-MSI platform for analyzing lipid distribution in 3D cell cultures, revealing metabolic interactions in cancer models.

Suppression of systemic T cell immunity to viral infection during liver injury is prevented by inhibition of interferon and IL-10 signaling

The paper shows that liver injury suppresses systemic T cell immunity to viral infection, which can be reversed by inhibiting interferon and IL-10 signaling in preclinical models and human patients.

Impact of different mutations on Kelch13 protein levels, ART resistance and fitness cost in Plasmodium falciparum parasites

This study examines how mutations in K13 and related genes affect ART resistance, protein levels, and fitness cost in Plasmodium falciparum parasites, finding no benefit from double mutations but highlighting the fitness cost of ubp1R3138H.

Preclinical establishment of a divalent vaccine against SARS-CoV-2

This paper develops a divalent vaccine against SARS-CoV-2 that induces strong IgG responses and T-cell activation, showing durability and cross-variant protection.

DiversityScanner: Robotic discovery of small invertebrates with machine learning methods

DiversityScanner automates invertebrate sorting and classification using a robot and CNN, achieving 91.4% precision in identifying 14 insect classes and estimating biomass.

Fresh insights into Mediterranean biodiversity: Environmental DNA reveals spatio-temporal patterns of stream invertebrate communities on Sicily

The paper uses eDNA metabarcoding to study stream invertebrate biodiversity in Sicily, finding seasonal diversity changes and a dispersal barrier.

RTK-dependent inducible degradation of mutant PI3K alpha drives GDC-0077 (Inavolisib) efficacy

The paper shows that GDC-0077 and taselisib degrade mutant PI3K alpha via HER2-dependent mechanisms, enhancing efficacy in PIK3CA-mutant breast cancer.

Reverting the mode of action of the mitochondrial FOF1-ATPase by Legionella pneumophila preserves its replication niche

This study shows Legionella pneumophila reverses the mitochondrial FOF1-ATPase to preserve membrane potential and delay macrophage death, supporting bacterial replication.

Therapeutic reversal of prenatal pontine ID1 signaling in DIPG

This study identifies ID1 upregulation in DIPG tumor cells and shows that CBD can reduce ID1-driven invasiveness in vitro and in vivo.

Identification and Characterization of Human Activation-Induced ChAT+CD4+ T Cells

The paper identifies and characterizes human ChAT+CD4+ T cells, showing their induction by activation and association with vasorelaxation and improved survival in critically ill patients.

Social behaviour and vocalizations of the tent-roosting Honduran White Bat

This study documents the social behavior and vocalizations of the Honduran white bat, identifying 16 behaviors and 10 social call types in wild groups.

Glycocalyx-mediated Cell Adhesion and Migration

This study shows the glycocalyx enables cell adhesion and amoeboid migration through nanoscale interactions and mechano-coupling, independent of integrin function.

The thrombopoietin receptor agonist eltrombopag inhibits human cytomegalovirus replication via iron chelation

This paper shows eltrombopag inhibits HCMV replication via iron chelation, effective against drug-resistant strains and synergistic with ganciclovir.