CTLA-4 regulates PD-L1-PD-1 interactions via transendocytosis of CD80
A. Kennedy, M. Robinson, C. Hinze, E. Waters, C. Williams, N. Halliday, S. Dovedi, D. Sansom
The paper investigates how CTLA-4 regulates PD-L1-PD-1 interactions through CD80 transendocytosis, showing that CD80 removal enables PD-L1 recovery and that CTLA-4's cytoplasmic domain is essential for this process.
bioRxiv · Mar 28, 2022 · PreprintImmunology